Thymosin Alpha-1: The Immunomodulatory Thymic Peptide

Thymosin alpha-1 belongs to the small set of peptides that started as a glandular isolation and became a reference compound for an entire research direction — in this case, how peptides shape the immune response.

The molecule

Thymosin alpha-1 is a 28-amino-acid peptide (C₁₂₉H₂₁₅N₃₃O₅₅, ≈ 3108 g/mol), first isolated from thymic tissue by Goldstein and colleagues (PNAS, 1977). Its name reflects its origin: it was one of the first thymic peptides to be purified and sequenced.

What the research looks at

• Immune-response modulation — the central thread; effects on immune effector function in various models
• T-cell maturation and function — thymic lineage research from the original isolation onward
• Toll-like-receptor signaling — a more recent mechanistic angle connecting the peptide to innate immunity
• Inflammatory balance — studied as a host-defense peptide that modulates rather than suppresses

Handling notes

Lyophilized, reconstitute with bacteriostatic water; the reconstitution calculator handles the math. Store at −20°C lyophilized.

See Thymosin Alpha-1 for CAS, purity and full specifications.

For laboratory research use only. Not medical advice.