Sermorelin: GHRH 1-29 for GH-Axis Reference Research

Sermorelin answers a structural question: how much of the growth-hormone-releasing hormone molecule is actually needed for receptor activity? The answer the research settled on is the first 29 residues — and that fragment became a reference standard in its own right.

The molecule

Sermorelin is GHRH 1-29 NH2 (C₁₄₉H₂₄₆N₄₄O₄₂S, ≈ 3358 g/mol) — the N-terminal 29 amino acids of human GHRH. Studies established that this portion carries the receptor-active region of the full 44-mer, which is why it is studied both as an analog and as a structural reference point.

What the research looks at

• GHRH-receptor binding assays — a standard comparator for the GHRH receptor
• Pulsatile GH secretion — how GHRH-R signaling shapes the amplitude and timing of growth-hormone pulses
• GH-axis pharmacology — baseline reference for comparing longer or modified analogs

How it fits the GHRH family

Sermorelin is the reference fragment; Tesamorelin is the stabilized full 44-mer, and CJC-1295 No DAC (Mod GRF 1-29) is the same 29-mer with four substitutions for DPP-IV resistance. Reading the three side by side is a clean illustration of how length and substitutions trade off against stability in GHRH research.

Handling notes

Lyophilized, reconstitute with bacteriostatic water; the reconstitution calculator handles the math. Store at −20°C lyophilized.

See Sermorelin for CAS, purity and full specifications.

For laboratory research use only. Not medical advice.