Selank: The Tuftsin-Related Anxiolytic Heptapeptide

Selank comes from a place most research peptides don’t: it was deliberately built around an immune peptide. Its sequence descends from tuftsin, a natural immunomodulatory tetrapeptide, which is why its research profile spans both the nervous system and inflammatory signaling.

The molecule

Selank is the heptapeptide Thr-Lys-Pro-Arg-Pro-Gly-Pro (C₃₃H₅₇N₁₁O₉, ≈ 752 g/mol). The first four residues are tuftsin (Thr-Lys-Pro-Arg), and the extension was designed to stabilize it against enzymatic degradation — a common trick in synthetic peptide development.

What the research looks at

Selank research clusters around three threads:

• Anxiolytic and nootropic effects — studied in behavioral models of anxiety and cognitive performance, with an unusual absence of sedation at tested doses
• Monoamine system modulation — serotonin and dopamine signaling are recurring points of investigation
• Inflammatory-cytokine balance — the tuftsin lineage makes immune-cytokine interaction a distinctive research angle for a peptide studied in the CNS

Because it shares design lineage with Semax, the two are frequently studied as a pair — the Semax page covers the cognitive arm.

Handling notes

Lyophilized, reconstitute with bacteriostatic water; the reconstitution calculator handles the math. Store at −20°C lyophilized.

See Selank for CAS, purity and full specifications.

For laboratory research use only. Not medical advice.