PT-141 (Bremelanotide): The MC4R-Selective Cyclic Peptide

PT-141 is what happens when a research team takes a non-selective peptide and asks: what if we could pick just one receptor? It is the MC4R-selective derivative of Melanotan II, and that selectivity is the entire research story.

The molecule

PT-141 (bremelanotide, C₅₀H₆₈N₁₄O₁₀, ≈ 1025 g/mol) is a cyclic heptapeptide derived from the Melanotan II scaffold. The scaffold itself is a cyclic α-MSH analog; the PT-141 modification shifts selectivity toward the melanocortin-4 receptor (MC4R), redirecting research interest from MC1-driven pigmentation to MC4-driven neuroendocrine signaling.

What the research looks at

• MC4-receptor pharmacology — the selectivity story; binding and signaling studies against the non-selective parent
• Neuroendocrine and behavioral models — MC4 pathways intersect energy balance, autonomic regulation and behavior
• Melanocortin signaling beyond pigmentation — the broader question of what MC receptors do outside melanogenesis

Handling notes

Lyophilized, reconstitute with bacteriostatic water; the reconstitution calculator handles the math. Store at −20°C lyophilized, protect from light.

See PT-141 for CAS, purity and full specifications.

For laboratory research use only. Not medical advice.