Kisspeptin-10: The Kiss1 Receptor Ligand in GnRH Research

Kisspeptin-10 has one of the most memorable names in peptide research, and one of the clearest jobs: it is the ligand that sits upstream of the reproductive hormone cascade, and its discovery rewired how reproductive neuroendocrinology is understood.

The molecule

Kisspeptin-10 is the C-terminal decapeptide (C₆₃H₈₃N₁₇O₁₄, ≈ 1302 g/mol) of the Kiss1/metastin peptide family. It is the high-affinity endogenous ligand of the GPR54 receptor (KISS1R). The gene was named for Hershey’s Kisses — the candies made in Hershey, Pennsylvania — a naming story from the original 2001 Nature discovery paper by Ohtaki and colleagues.

What the research looks at

• GnRH pulsatility and puberty — kisspeptin is a master regulator of GnRH neuron activity; puberty onset research is a core thread
• Reproductive neuroendocrinology — the kisspeptin-GnRH-GnIH axis
• KISS1R receptor pharmacology — binding and signaling studies for GPR54

Handling notes

Lyophilized, reconstitute with bacteriostatic water; the reconstitution calculator handles the math. Store at −20°C lyophilized.

See Kisspeptin-10 for CAS, purity and full specifications.

For laboratory research use only. Not medical advice.